CMV duodenitis (histology)

Case contributed by Dr Andrew Ryan

Presentation

Dyspepsia. Past history of AML with transplant.

Patient Data

Age: 55 years
Gender: Male
pathology

The biopsies of the duodenum shows scattered enlarged cells containing both large intranuclear inclusions and basophilic (more purple) intracytoplasmic inclusions.

Case Discussion

While CMV viral inclusions can be seen in enterocytes, they are more commonly identified in endothelial cells or stromal cells. When prominent, enterocyte inclusions should raise the differential diagnosis of adenovirus infection however cells infected with adenovirus should show inclusions restricted to the nucleus and do not show 'cytomegaly' (cell enlargement).

How to use cases

You can use Radiopaedia cases in a variety of ways to help you learn and teach.

Creating your own cases is easy.