CNS lymphoma

Case contributed by Frank Gaillard


Previous illness (withheld) now increasing confusion.

Patient Data

Age: 60 years
Gender: Male

Extensive periventricular contrast enhancement is seen lining the ependymal surface or all ventricles, most pronounced in the lateral ventricles of both hemispheres. There is associated increased T2 signal extending into the white matter. The contrast enhancing tissue demonstrates prominent restricted diffusion (ADC 500-600). Ventricular size is essentially normal. 

Case Discussion

This patient had had previously diagnosed lymphoma, and now had a cerebral recurrence. The patient went on to have a biopsy.



The sections show a densely cellular malignant tumor in the white matter. It forms diffuse sheets and cuffs around the blood vessels. The tumor cells are intermediate in size. They have enlarged clefted and hyperchromatic nuclei, prominent nucleoli and scanty cytoplasm.

The tumor cells are CD20, PAX-5, bcl-2, bcl-6 and MUM1 positive. The Ki-67 index is about 80%. They are CD3 and CD10 negative. There is insufficient tissue for EBER-CISH. The features are those of diffuse large B-cell lymphoma with activated B-cell-like phenotype.


Diffuse large B-cell CNS lymphoma.

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