CNS lymphoma - multiple small periventricular

Case contributed by A.Prof Frank Gaillard
Modality: MRI

Patchy nodular regions of enhancement are seen in the left frontal lobe as well as beside the lateral ventricles, including the corpus callosum. 

Case Discussion

Final Diagnosis:

Brain tumor: B-cell lymphoma

Microscopic Description:

Sections show small fragments of brain tissue which are diffusely infiltrated by reactive and atypical lymphoid cells. The atypical cells have pleomorphic round nuclei with little visible cytoplasm and show immunoreactivity for the B-cell marker CD20. A smaller population of normal appearing CD3 positive reactive T-lymphocytes is also present. The atypical cells show prominent mitotic activity and there are focal areas of necrosis. Reticulin stain highlights the perivascular and intravascular pattern

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Case Information

rID: 5426
Case created: 20th Jan 2009
Last edited: 7th Dec 2015
Inclusion in quiz mode: Included

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