CNS lymphoma (primary)

Case contributed by A.Prof Frank Gaillard
CT

Single image from a non-contrast CT demonstrates a vague bilateral hyperdensity crossing the midline. 

MRI

Vividly enhancing mass extends across the corpus callosum. It demonstrates diffusion restriction and is centrally relatively low in T2 signal. 

Pathology

 

MICROSCOPIC DESCRIPTION:

Paraffin section of the specimen [...] shows accumulation of large atypical mononuclear cells around small calibre vascular channels with invasion of the walls of some vessels noted. The atypical cells have large round, oval and angulated hyperchromatic and vesicular nuclei and a narrow rim of plae cytoplasm. An occasional mitotic figure is noted. These atypical cells show strong surface immunostaining for the B lymphocyte markers, CD20 and CD79a. A moderate number of small mature CD3+ T lymphocytes are also present.

DIAGNOSIS:

Non Hodgkin's large B cell lymphoma.

Case Discussion

This case is fairly typical of CNS lymphoma which has a predilection from crossing the midline. 

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Case information

rID: 3975
Case created: 6th Jul 2008
Last edited: 12th Jun 2016
Inclusion in quiz mode: Included

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