Congenital cerebral toxoplasmosis
Citation, DOI, disclosures and case data
At the time the case was submitted for publication Alberto Martínez Calvo had no recorded disclosures.View Alberto Martínez Calvo's current disclosures
Headaches. Sleep and behavior disorders.
Loading Stack -
0 images remaining
Multiple scattered bilateral cerebral calcifications, predominantly in corticomedullary junction.
Additional findings and history was available: congenital intumescent cataract, microphthalmos, microcornea and chorioretinitis in the right eye. Documented history of toxoplasmosis in pregnancy.
Congenital toxoplasmosis is the second most common congenital infection, caused by intrauterine infection with the protozoan parasite Toxoplasma gondii that is found worldwide.
The presence of chorioretinitis, intracranial calcifications, and hydrocephalus is considered the classic triad of congenital toxoplasmosis. Fever, hydrocephalus or microcephaly, hepatosplenomegaly, jaundice, convulsions, chorioretinitis (often bilateral), cerebral calcifications, and abnormal cerebrospinal fluid are the classic features of severe congenital toxoplasmosis.
Imaging features of congenital toxoplasmosis resemble those of CMV, Zika, and LCMV.
NECT scans show extensive parenchymal calcifications that often appear "scattered" throughout the brain parenchyma.
In this case, the history of toxoplasmosis in pregnancy is the diagnostic key.
- 1: McAuley JB. Congenital Toxoplasmosis. J Pediatric Infect Dis Soc. 2014 Sep;3 Suppl 1:S30-5. doi: 10.1093/jpids/piu077. PubMed PMID: 25232475; PubMed Central PMCID: PMC4164182.
- 2: Osborn's Brain. Imaging, pathology and anatomy. A. G. Osborn. Second Edition. Congenital, Acquired Pyogenic, and Acquired Viral Infections.
1 article features images from this case
11 public playlists include this case
- congenital infection by Monia Almoktar
- Neonates by Muhammad AlMatter
- Neuro per review 5 by Francesco Buemi ◉
- CNS infections by Xien Liversidge ◈
- Placenta, Chromosomal, Gestations, Pregnancy, Wellbeing by F L
- infección perinatal by Juan Sebastián Alonso Ojeda Gómez
- Neuro-inflamatory, infections and neurodegenerative by Peneoasu Cristian
- Casos 1 - Neuroradiología by Diana Carolina García García
- paeds by Frank Dorrian
- Brain imaging by Kamil Kayayurt
- CNS 6 - Intracranial Calcifications by Praveen Samarawickrama