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Congenital cytomegalovirus infection CNS sequelae

Case contributed by Dr Bruno Di Muzio


Child with seizures. Confirmed history of gestational CMV infection.

Patient Data

Age: 2-year-old
Gender: Male

MRI imaging showing bilateral parietooccipital gyri architectural distortion characterized by microgyria, focal volume loss, and high T2/FLAIR signal in the white matter. The posterior horns of the lateral ventricles are prominent in an ex-vacuo component. Corpus callosum is formed, however, there is a thinning of the splenium. 

Case Discussion

Although those MRI findings are non-specific, in the context of a confirmed congenital cytomegalovirus infection, they are consistent with CNS sequelae of congenital infection

CMV is the most common cause of intra-uterine infection and most common cause of congenital infective and brain damage. 

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