Congenital cytomegalovirus infection CNS sequelae
Child with seizures. Confirmed history of gestational CMV infection.
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MRI imaging showing bilateral parietooccipital gyri architectural distortion characterised by microgyria, focal volume loss, and high T2/FLAIR signal in the white matter. The posterior horns of the lateral ventricles are prominent in an ex-vacuo component. Corpus callosum is formed, however, there is a thinning of the splenium.
CMV is the most common cause of intra-uterine infection and most common cause of congenital infective and brain damage.