Corpus callosum agenesis

Case contributed by Dr Sameh Saied Ali

Presentation

Generalized tonic clonic seizures and delayed milestones.

Patient Data

Age: 7 months
Gender: Male
Modality: MRI

MRI study shows: 

  • a complete absence of the corpus callosum
  • absent cingulate sulcus with the medial hemispheric sulci seen reaching the third ventricle in a radial fashion
  • dilated high riding third ventricle
  • parallel configuration of the lateral ventricles

Case Discussion

Agenesis/dysgenesis of the corpus callosum is an anomaly that may occur in isolation or in association with other CNS or systemic malformations. 

It may be complete, partial, or atypical: 

  • with complete agenesis, the corpus callosum is totally absent
  • with partial agenesis (hypoplasia), the anterior portion (posterior genu and anterior body) is formed, but the posterior portion (posterior body and splenium) is not. The rostrum and the anterior/inferior genu are also not formed

It is important to be aware of the features of agenesis of the corpus callosum. First, to distinguish it from hydrocephalus and second to instigate a search for further, more serious, anomalies with which it may be associated.

MRI is currently the imaging modality of choice in infants and children with agenesis/dysgenesis of the corpus callosum, even in patients who have previously undergone CT and US examinations.

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Case Information

rID: 36683
Case created: 4th May 2015
Last edited: 22nd Apr 2017
Inclusion in quiz mode: Included

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