Case contributed by A.Prof Frank Gaillard

Patient Data

Age: Adult
Gender: Male

CT brain

Suprasellar mass, predominantly of intermediate to fluid attenuation without convincing calcification.


MRI pituitary

Selected sagittal and coronal pre and post contrast images demonstrate a multicystic/solid mass in the suprasellar region, with intrinsic high T1 signal. 

Case Discussion

The patient went on to have a resection.


The section shows a single small fragment of tissue. This is composed of irregularly shaped islands of mature squamous epithelium which are dispersed in a loose fibrous stroma. These show strong immunostaining  for cytokeratins AE1/AE3 and CAM5.2. The stroma contains aggregates of keratin. Focal foreign-body type granulomatous inflammation in association with some collections of keratin are noted. There is also focal dystrophic calcification. No cyst formation is seen. The features are those of a craniopharyngioma.

Unfortunately, in my experience at multiple hospitals, histology reports often do not explicitly distinguish between papillary and adamantinomatous subtypes.

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Case information

rID: 2728
Published: 17th May 2008
Last edited: 13th Aug 2019
Inclusion in quiz mode: Included

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