Creutzfeldt-Jakob disease

Case contributed by Francesco Buemi
Diagnosis almost certain

Presentation

Progressive dementia and myoclonus.

Patient Data

Age: 55 years
Gender: Female
mri

Abnormal high T2 and DWI signal (low signal on ADC) in the putamina, caudate nuclei and dorsomedial thalami (hockey stick sign). 

Case Discussion

Cerebrospinal fluid was positive for 14-3-3 protein consistent with a diagnosis of Creutzfeldt-Jakob disease.

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