Loss of short-term memory and difficulty performing normal daily actions for three months.
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T2-hyperintense and diffusion restrictive appearance of the frontal and parietooccipital cortex.
No lesions or edema in the white matter, basal ganglia or posterior fossa.
MR-findings matching with Creutzfeldt-Jakob disease.
In this case, the cerebrospinal fluid was positive for the 14-3-3 protein and the RT-QuIC test was also positive, making the diagnosis certain.
- The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt-Jakob disease in the UK: a 10-year review. Chohan G, Pennington C, Mackenzie JM, Andrews M, Everington D, Will RG, Knight RS, Green AJ. J Neurol Neurosurg Psychiatry. 2010;81(11):1243–1248.
- Qavi A H, Imran T F, Hasan Z, et al. (March 14, 2017) Serial Magnetic Resonance Imaging in Creutzfeldt-Jakob Disease: a Case Report and Literature Review. Cureus 9(3): e1095.