Creutzfeldt-Jakob disease (CJD)
Diagnosis certain
Updates to Case Attributes
Age
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Presentation
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A 55-year-old woman with 4 month-month history of rapid functional and cognitive decline. Initial symptoms were depression and sleep disturbance. She then developed myoclonic jerks and ataxia.
Body
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Cerebrospinal fluid was positive for 14-3-3 protein consistent with a diagnosis of Creutzfeld-Jakob disease (CJD).
Note the high signal in the caudate heads and putamen on FLAIR. There is also some cortical ribboning seen on DWI.
From a psychiatric point of view, it is important to be aware that the earliest clinical manifestations of CJD can be mental state changes and patients may initially present with a complaint such as depression.
-<p>Cerebrospinal fluid was positive for 14-3-3 protein consistent with a diagnosis of <a title="Creutzfeld-Jakob disease" href="/articles/creutzfeldt-jakob-disease">Creutzfeld-Jakob disease</a> (CJD). </p><p>Note the high signal in the caudate heads and putamen on FLAIR. There is also some cortical ribboning seen on DWI. </p><p>From a psychiatric point of view it is important to be aware that the earliest clinical manifestations of CJD can be mental state changes and patients may initially present with a complaint such as depression. </p>- +<p>Cerebrospinal fluid was positive for 14-3-3 protein consistent with a diagnosis of <a href="/articles/creutzfeldt-jakob-disease">Creutzfeld-Jakob disease</a> (CJD). </p><p>Note the high signal in the caudate heads and putamen on FLAIR. There is also some cortical ribboning seen on DWI. </p><p>From a psychiatric point of view, it is important to be aware that the earliest clinical manifestations of CJD can be mental state changes and patients may initially present with a complaint such as depression. </p>
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Question
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How would you explain the high signal on diffusion weighted-weighted imaging?
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Image MRI (DWI) ( update )
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Image MRI (DWI) ( update )
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Image 7 MRI (FLAIR) ( update )
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