Creutzfeldt-Jakob disease

Case contributed by Dr Maxime St-Amant

Presentation

Headaches and memory loss in a young patient.

Patient Data

Age: 45 years
Gender: Male

MRI shows subtle abnormal signal intensity in the basal ganglion, particularly evident within the caudate nucleus.

The basal ganglia are hyperintense on DWI (not shown, but hypointense on ADC) & slightly hyperintense on T2. As mentioned previously, this is more evident with regard to the caudate nucleus. There is no abnormal cortical signal or diffusion restriction. 

Case Discussion

There is a broad differential diagnosis for T2 basal ganglia hyperintensities.

However, the diagnosis of Creutzfeldt-Jakob was confirmed a few weeks after the MRI was done. DWI is the most sensitive sequence for this disease.

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