Cryptogenic organising pneumonia


Dyspnoea, cough and fevers. Post bone marrow transplant (BMT) for mantle cell lymphoma. Previous COP.

Patient Data

Age: 50
Gender: Male

Bilateral ill-defined nodular opacities throughout both lungs with more confluent consolidation in the left upper lobe is evident.  Several of the nodules have apparent central lucency which is suspicious for cavitation. The lung volumes are reduced. There is no pleural fluid and the cardiac and mediastinal contour is normal.

COP may explain the reduced volume lungs and more peripheral confluent areas of consolidation, particularly in the left upper lobe. The possibility of cavitating nodules is however not easily explained and in the immunocompromised patient consideration to invasive aspergillosis or other atypical infections should be given.

Multifocal areas of nodular consolidation and ground glass opacity in a predominantly peribronchial and subpleural distribution, slightly worse in the upper lobes demonstrated.  No cavitation, intrapulmonary mass or significant collapse seen. 

Tiny bibasal pleural effusions. A few small pretracheal nodes, however no significant hilar, mediastinal, supraclavicular or axillary lymphadenopathy.

Heart and pericardium within normal limits. No pericardial effusion Visualised upper abdominal organs are unremarkable. High density material in the stomach and duodenum noted of uncertain significance.  No bony destructive lesions seen in visualised spine, ribs or shoulder girdle. 

Conclusion: Multifocal nodular consolidation and ground glass opacity subpleural and peribronchial in distribution very suggestive of COP. It would be important to correlate with time post BMT. Other differentials , such as atypical fungal infection such as aspergillosis, are thought less likely. 


Bronchial washings: acute inflammation

Case Discussion

Typical appearances of cryptogenic organising pneumonia. No definite features of infection on laboratory examination. 

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Case information

rID: 21992
Published: 3rd Mar 2013
Last edited: 16th Jul 2018
System: Chest
Inclusion in quiz mode: Included

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