Case contributed by Dr Manisha Langar


A Gujjar patient presented for routine antenatal ultrasound in third trimester for the first time.

Patient Data

Age: 29 years
Gender: Female

Single intrauterine fetus was seen.


A single midline orbit and an overlying process was seen (proboscis).

Fetal head size was small for gestation age & holoprosencephaly was seen. 

Nasal bones were absent. Fetal lips were normal.

Case Discussion

Cyclopia is an extremely rare type of congenital malformation & is part of a spectrum of anomalies occurring in holoprosencephaly.

This group of congenital anomalies occurs due to to abnormal differentiation & cleavage of the prosencephalon. There is anomalous formation of the central cavity of the orbit, with absence of the nasal cavity. A rudimentary bony process is formed over the orbital cavity called proboscis.

True cyclopia is an extreme form, where  only a single orbit is present. But two globes may be found in different degrees of fusion, called synopthalmos.

Associated mid line facial deformities like midfacial clefts, primitive nasal structures & hypotelorism, may be there.

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Case information

rID: 34442
Published: 24th Feb 2015
Last edited: 28th Dec 2019
System: Obstetrics
Inclusion in quiz mode: Excluded

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