Cystic nephroma: gross pathology and histology

Case contributed by Dr Andrew Ryan

Presentation

Multilocular cystic lesion on imaging.

Patient Data

Age: 50

Partly collapsed but well circumscribed multilocular cystic lesion in the upper pole of the kidney

Histology showing variably sized cysts separated by thin septae lined by benign 'non-clear cell' epithelium.

Low power (x10) histology showing variably sized cysts separated by thin septae, with a small amount of adjacent parenchyma (upper left).

Medium power (x200) histology showing variably sized cysts separated by thin septae composed of fibrous to spindled stroma, in areas with 'ovarian-like' qualities. 

High power (x400) histology showing fibrous to spindled septae lined by bland epithelium with 'hob-nail' appearance.

Case Discussion

Cystic nephroma is an uncommon benign lesion of the kidney, most often presenting as a well circumscribed multilocular cyst. The important differential diagnosis to exclude in adults is cystic renal cell carcinoma. 

PlayAdd to Share

Case information

rID: 46614
Case created: 11th Jul 2016
Last edited: 26th Mar 2018
System: Urogenital
Inclusion in quiz mode: Excluded

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.