Cytotoxic lesion of the corpus callosum

Case contributed by Zentout Sofiane


Seizures, fever and mental confusion.

Patient Data

Age: 15 years
Gender: Male

There is a focal lesion of the splenium of the corpus callosum with T1 iso-intense signal, high signal on T2, and FLAIR and restriction of diffusion with no enhancement.

Case Discussion

Cytotoxic lesions of the corpus callosum (CLOCC) are acquired lesions. CLOCC are secondary lesions associated with various entities including seizure(with or without antiepileptic medication), metabolic disorders, (such as hypoglycemia, hypernatremia, acute alcohol poisoning, malnutrition, and Vit B12 deficiency ), malignancy, lupus erythematosus, eclampsia and status migrainosus.

Follow-up is recommended.


Additional Contributor: DR BOUKHAMLA MOHAMED CHERIF, radiologist.

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