Deep, benign fibrous histiocytoma

Case contributed by Dr Chris O'Donnell


Slowly enlarging, non-painful swelling over the right supraorbital ridge

Patient Data

Age: 60
Gender: Female

Crescentic T1 and T2 hypointense subcutaneous mass overlying the skull vault with diffuse Gadolinium enhancement


Ultrasound was used to guide percutaneous biopsy

Crescentic solid mass with minor pressure erosion on the outer table of skull.  Biopsy result is "low grade spindle cell proliferation with immunocytochemistry (positive CD 68, positive CD 163 and positive factor XIIIa, negative EMA and SMA) suggesting benign fibrous histiocytoma"

Case Discussion

Benign fibrous histiocytoma is one of the most common mesenchymal neoplasms of the skin and is cutaneous in location. Deep benign fibrous histiocytoma  is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deeper soft tissue such as in this case. They are clinically more significant as they can be associated with local recurrence post excision. Rarely they can metastasize.

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Case information

rID: 32080
Published: 24th Dec 2014
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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