Desmoplastic infantile ganglioglioma

Case contributed by Dr Odina Gomez


Vomiting for 5 days.

Patient Data

Age: 5 months
Gender: Female

MRI Brain

Large, mixed signal intensity mass that is predominantly multicystic, multiseptate with heterogeneously enhancing solid lobulated component in the right middle cranial fossa centered in the right temporal lobe.  It exhibits significant mass effect effacing the right frontal and parietal lobes, and causing leftward subfalcine and downward transtentorial herniation.  There is compression of the right lateral ventricle, and mild dilatation of the left lateral ventricle.  



Brain ultrasound

Large, multiseptate cystic mass located predominantly in the right frontal and temporal lobes, causing right lateral ventricular compression and subfalcine herniation

Case Discussion

Post temporal craniotomy with subtotal excision of tumor was done and biopsy revealed a mature glial-neuronal tumor with collagenous matrix, marked desmoplasia, and proliferative primitive component for which the diagnosis of Desmoplastic infantile ganglioglioma (WHO Grade 1) was made. 

Desmoplastic infantile ganglioglioma is a rare supratentorial tumor of infancy characterized by its massive size with cystic and enhancing solid components, having a predilection to at least two hemispheric lobes particularly frontal and parietal.  The median age at diagnosis was more presumptuous at around 5 or 6 months as in this patient who initially presented with vomiting. Despite their aggressive radiologic features, such tumors were noted to have a good prognosis after surgery.

The radiologic differential diagnoses of desmoplastic infantile tumors include primitive neuroectodermal tumor (PNET), dysembryoplastic neuroepithelial tumor (DNET), ependymoma, and ganglioglioma.

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Case information

rID: 40211
Published: 13th Oct 2015
Last edited: 15th Mar 2021
Inclusion in quiz mode: Included

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