Diffuse astroctyoma

Case contributed by A.Prof Frank Gaillard

Presentation

Seizure.

Patient Data

Age: Middle aged adult
Modality: MRI

A low T1, high T2 signal mass is present on the left centered on the insular cortex with mild positive mass effect. No enhancement. 

Case Discussion

The patient had a craniotomy and resection of the mass. 

Histology

Paraffin sections show fragments of cerebral cortex and white matter.  The majority of these show no significant abnormality. However, there are several fragments of white matter, which are hypercellular and which show loss of the normal white matter architecture.  Within these fragments, there is a proliferation of mildly atypical astrocytic cells.  These have enlarged irregularly shaped hyperchromatic and vesicular nuclei and delicate processes.  No mitotic figures are seen and there is no evidence of vascular endothelial cell proliferation and no necrosis. Prominent perineuronal secondary structuring is noted in some areas of cortex. The features are of diffuse astrocytoma (WHO grade II). 

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Case Information

rID: 10183
Case created: 19th Jul 2010
Last edited: 20th Nov 2015
Tag: glioma
Inclusion in quiz mode: Included

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