Diffuse astroctyoma NOS

Case contributed by A.Prof Frank Gaillard

Presentation

Seizure.

Patient Data

Age: Middle aged adult
MRI

A low T1, high T2 signal mass is present on the left centered on the insular cortex with mild positive mass effect. No enhancement. 

Case Discussion

The patient had a craniotomy and resection of the mass. 

Histology

Several fragments of white matter are hypercellular and show loss of the normal white matter architecture.  Within these fragments, there is a proliferation of mildly atypical astrocytic cells.  These have enlarged irregularly shaped hyperchromatic and vesicular nuclei and delicate processes.  No mitotic figures are seen and there is no evidence of vascular endothelial cell proliferation and no necrosis. Prominent perineuronal secondary structuring is noted in some areas of cortex. 

FINAL DIAGNOSIS: Diffuse astrocytoma (WHO grade II). 

Note: IDH mutation status is not provided in this case and according to the current (2016) WHO classification of CNS tumours, this tumour would, therefore, be designated as a diffuse astrocytoma NOS.

 

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Case information

rID: 10183
Case created: 19th Jul 2010
Last edited: 22nd Jun 2017
Tag: glioma
Inclusion in quiz mode: Included

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