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Diffuse astrocytoma IDH-mutant

Case contributed by Assoc Prof Frank Gaillard


Left sided weakness.

Patient Data

Age: 40 years
Gender: Female

A large region of low attenuation with mass effect and no enhancement involves primarily the right parietal lobe, including the cortex. No calcification. 


Large left parietal mass with extensive cortical involvement, elevated choline and extension into the corpus callosum. No convincing enhancement. CBV is elevated. 


Features are those of a primary brain tumor. Extensive cortical involvement favors an oligodendroglial component. 

Case Discussion

The patient went on to have surgery.


MICROSCOPIC DESCRIPTION: Paraffin sections show fragments of a mildy hypercellular glial tumor. This consists predominantly of oligodendroglial cells which show mild nuclear pleomorphism. These are admixed with a quantitatively smaller population of atypical astrocytic cells. Scattered gliofibrillary oligodendrocytes are also noted and there is patchy reactive astrocytic gliosis. No mitotic figures are identified. There is no microvascular proliferation and no necrosis is identified. 


  • GFAP positive in tumor and reactive astrocytes and in gliofibrillary oligodendrocytes. 
  • Nogo A positive in tumor oligodendrocytes
  • IDH-1 R132H positive (mutated) 
  • MGMT positive (likely unmethylated). 
  • p53 positive. 
  • p16 positive. 
  • FISH for chromosome 1p/19q deletion:
    • 1p36: No loss detected
    • 19q13: No loss detected

Topoisomerase labeling index: Approximately 8%. 

FINAL DIAGNOSIS: Astrocytoma (WHO Grade II)


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Case information

rID: 36800
Published: 5th Jun 2016
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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