Diffuse astrocytoma NOS ("protoplasmic")
- Radiopaedia Australia Pty Ltd and Radiopaedia Events Pty Ltd, Director, Founder and CEO (Radiopaedia) (ongoing)
- Biogen Australia Pty Ltd, Investigator-Initiated Research Grant for CAD software in multiple sclerosis: finished Oct 2021 (past)
Updates to Study Attributes
A large An intra-axial mass lesion measuring distorts and displacesarises from the middle and inferior frontal gyri on the right with only minimal positive mass effect, despite its relatively large size.
The lesion's epicentre is extra-axial in natureof very high T2 signal, however, regionsand much of the signal abnormality are also identified within the cortex and the overlying white matter.
Compression of the right lateral ventricle is noted and thinning of the overlying diploic space is present. it at least partially suppresses on FLAIR.
There is no associated contrast enhancement, no raised cerebral blood volume and no evidence of diffusion restriction (in fact ADC values are markedly elevated)facilitated. MR spectroscopy at the periphery of the lesion demonstrates decreases in all metabolites (not shown).
ReviewConclusion:
This lesion most likely represents a diffuse adult-type glioma. In a 30-year-old, and the absence of the preceding CT scan shows thatcalcification and in the lesion is predominantlypresence of the low attenuationT2-FLAIR mismatch, this most likely represents an astrocytoma IDH-mutant. No evidence of fat or calcificationThere are no high-grade features.