Diffuse astrocytoma with gliomatosis cerebri growth pattern

Case contributed by Dr Farhad Farzam


Headache, seizure, left side body weakness and sometimes nausea/vomiting.

Patient Data

Age: 20 Years
Gender: Male

Cortico-subcortical abnormal signal intensity involving the right fronto-temporo-parietal lobes causing effacement of the right lateral ventricle. It is returning low to iso-signal in T1 WI, high signal in T2/FLAIR images without diffusion restriction in DWI and corresponding ADC map. No contrast enhancement is noted in the lesion in post contrast sequences.​

Case Discussion

​The imaging features are in favor of a diffuse astrocytoma (probably IDH-wt given age) with gliomatosis cerebri growth pattern. 

Note: In the 2016 update of WHO classification of CNS tumors, gliomatosis cerebri was removed as a stand-alone diagnosis. 

Unfortunately histology is unavailable for confirmation. 

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Case information

rID: 70456
Published: 22nd Aug 2019
Last edited: 23rd Aug 2019
Inclusion in quiz mode: Included
Institution: Kabul University of Medical Science

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