Diffuse glioma classification (WHO 2016)
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This flow chart represents the pathway from histological diagnosis of a diffuse glioma, down through IDH and 1p19q testing to a final diagnosis.
Note, that for probable glioblastomas there is the added qualifier of age, as IDH mutations are uncommon in the over 55 year-olds and as such sequencing is generally not recommended, provided there are no reasons to suspect a high likelihood of a mutation.
- Louis DN, Ohgaki H, Wiestler OD, Cavenee WK "WHO Classification of Tumours of the Central Nervous System. 4th Edition Revised" ISBN: 9789283244929