Diffuse glioma classification (WHO 2016)

Case contributed by Frank Gaillard

This flow chart represents the pathway from histological diagnosis of a diffuse glioma, down through IDH and 1p19q testing to a final diagnosis.

Note that for probable glioblastomas, there is the added qualifier of age, as IDH mutations are uncommon above 55 year-old and, as such, sequencing is generally not recommended, provided there are no reasons to suspect a high likelihood of a mutation. 

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