Diffuse large B-cell lymphoma (DLBCL)

Case contributed by Ammar Haouimi
Diagnosis almost certain

Presentation

Cough with retrosternal chest pain.

Patient Data

Age: 80 years
Gender: Male

The scout view demonstrates a left-sided anterior mediastinal mass with obtuse angles with the left mediastinal contour.

The CT scan demonstrates a heterogeneously enhancing left-sided anterior mediastinal soft tissue mass with lobulated contour in contact with the pulmonary trunk and left ventricle with moderate pericardial thickening. No other mediastinal mass or lymphadenopathy. No pleural effusion. Both lungs were clear (lung window not shown).

No distant abdominal or pelvic metastasis.

Other findings:

  • simple right renal cyst

  • small accessory spleen

  • small duodenal diverticulum

  • prostatic hypertrophy.

  • right inguinal hernia

On the MRI exam, the mediastinal mass elicits an isosignal to muscle on T1, high signal on T2 and T2 fat sat with progressive heterogeneous enhancement. No evidence of myocardial or pericardial invasion.

Annotated image

CT-guided biopsy showing the needle within the mediastinal mass.

Case Discussion

CT and MRI features of a heterogeneously enhancing left-sided anterior mediastnal mass with no distant metastasis.

The patient went on to have a CT-guided biopsy that confirms the diagnosis of a diffuse large B-cell lymphoma which is considered the most common subtype of non-Hodgkin lymphoma.

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