Diffuse large B-cell lymphoma of ileum: gross pathology and histology

Case contributed by Dr Andrew Ryan

Presentation

Small bowel thickening on CT. Past history of AML with bone marrow transplant.

Patient Data

Age: 50
Gender: Female

Terminal ileal thickening and ulceration.

Histological examination confirmed surface ulceration with destruction and replacement of the underlying submucosa and muscle wall by undifferentiated tumour arranged in sheets. These are confirmed on immunohistochemistry to be lymphoid (B-cell) in nature.  

Case Discussion

Lymphoma of the small bowel is rare and more commonly mucosal based and of T-cell origin. This case shows involvement of the small bowel by a high grade, infiltrative and destructive lymphoma, with histological and immunohistochemical features in keeping with diffuse large B-cell lymphoma (DLBCL). 

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Case Information

rID: 27602
Case created: 10th Feb 2014
Last edited: 10th Sep 2016
Inclusion in quiz mode: Excluded

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