Dural metastases from breast cancer

Case contributed by A.Prof Frank Gaillard

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Case Discussion

Final Diagnosis: 

Brain, left frontal: Metastatic carcinoma, consistent with metastatic carcinoma of breast origin. Immunohistochemical profile: strong Estrogen receptor immunoreactivity (+3), modest progesterone receptor immunoreactivity (+1), and variable and equivocal C-ERB (Her-2-neu)

Microscopic Description: 

Sections show metastatic carcinoma associated with dura and infiltrating brain parenchyma. Diffuse sheets and nests of neoplastic cells with foci of necrosis characterize the tumour. The individual tumour cells show pleomorphic nuclei with vesicular chromatin and prominent nucleoli, and distinct cellular borders. Immunohistochemical studies show immunoreactivity for Gross cystic disease fluid protein (GCDFP) and CK7, and immuno-negativity for CK20. The tumour cells display strong Estrogen receptor immunoreactivity (+3), modest progesterone receptor immunoreactivity (+1), and variable and equivocal C-ERB (Her-2-neu) immunoreactivity (+2).

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Case information

rID: 5262
Case created: 28th Dec 2008
Last edited: 7th Dec 2015
Tag: mets
Inclusion in quiz mode: Included

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