Dysembryoplastic neuroepithelial tumour (DNET)
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25 year old woman with intractable epilepsy.
Sections show brain tissue, including cerebral cortex and white matter, with areas of a relatively localized and superficial low-grade glial tumour. The tumour cells are fibrillar, and in areas display a bipolar appearance. There is a propensity for perivascular localization with nuclear-free zones between vessels. Mitotic activity is not increased. Vascular neurogenesis is not seen. Necrosis is not evident. Some areas display a loose hypocellular and cystic background. Small microcystic areas are also focally evident. Individual tumour cells are round to oval-shaped, and elongated, depending on the orientation. Some granular bodies are seen. Floating neurons are not well-defined, although entrapped neurons are observed within several parts of the tumour. In some areas, the pattern of architectural arrangement of neurons is irregular, consistent with focal cortical dysplasia. A ganglion cell component of a ganglioglioma is not definitively excluded.
Brain, orbital frontal cortex: Dysembryoplastic neuroepithelial tumour.