Dysembryoplastic neuroepithelial tumour (DNET)

Case contributed by A.Prof Frank Gaillard



Patient Data

Age: Adult

MRI through the temporal lobes of a patient with seizures demonstrates a high T2, low T1 region within the anterior mesial temporal lobe on the right. The central high T2 region does not attenuate on FLAIR.  

Case Discussion

In cystic cortical tumours involving the temporal lobe, the general differential diagnosis includes:

  1. DNET
  2. PXA
  3. ganglioglioma

The patient went on to have a resection. 


Microscopic Description:  Sections of the mesial structures show no evidence of mesial emporal sclerosis, or of significant dysplasia of the hippocampal formation. A dysembryoplastic neuroepithelial tumor is identified within white matter with focal extension within proximity of the dentate gyrus. The tumor is characterized by microcystic elements, scattered neurons, and oligodendroglial like cells that are occasionally organized in delicate cord-like structures. Features of cerebral microdysgenesis are evident in close proximity to the tumor, represented by small nodular aggregates of oligodendroglial like cells, and focal aggregates of neurons. Numerous corpora amylacea are observed within subpial regions, particularly in the vicinity of CA2.

Final Diagnosis: Dysembryoplastic neuroepithelial tumor (DNET). No evidence of mesial temporal sclerosis.

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Case information

rID: 4086
Case created: 18th Jul 2008
Last edited: 12th Jun 2016
Inclusion in quiz mode: Included

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