Ectopic posterior pituitary

Case contributed by Dr Yusra Sheikh

Presentation

15 day old neonate presenting with micropenis, hypoglycaemia, micrognathia, flat LHRH test, abnormal synacthen test suggestive of hypoadrenalism ?hypopituitarism.

Patient Data

Age: 15 days old
Gender: Male
Modality: MRI

There is no normal anterior pituitary gland tissue identified. There is a 0.3 cm T1W hyperintense nodule in the hypothalamus in keeping with a heterotopic posterior pituitary lobe. No other structural brain abnormality is identified in the remainder of the study.

Case Discussion

An ectopic posterior pituitary reflects a disruption of normal embryogenesis and is one of the more common causes of pituitary dwarfism. Although it can be an isolated abnormality, numerous other congenital central nervous system malformations have been identified.

No treatment is required for the ectopic pituitary per se, but rather for the frequently associated growth hormone deficiency, or less frequently panhypopituitarism. Growth hormone replacement is available in selected patients and can improve adult height.

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Case Information

rID: 44531
Case created: 26th Apr 2016
Last edited: 26th Oct 2016
Inclusion in quiz mode: Included

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