Extramedullary hematopoiesis

Case contributed by Anthony Nuñez


History of multiple myeloma, autologous stem cell transplantation and febrile neutropenia.

Patient Data

Age: 65 years
Gender: Male

Homogeneous soft tissue lesions are seen in the right posterior mediastinum adjacent to vertebral bodies.

Mild splenomegaly is noted.

The examined bones and the spine show diffuse punctate osteolytic marrow lesions.

Case Discussion

The most common sites of extramedullary hematopoiesis are the liver and the spleen, although any organ could be involved. 

Thoracic involvement is less common and manifests as the presence of lobulated masses adjacent to the spinal column.

In this patient, there is also seen splenomegaly. 

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