Revision 1 for 'Extraosseous langerhans cell histiocytosis'All Revisions
Langerhans cell histiocytosis
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder that characterized by granulomatous infiltration of the lung, bone,skin,lymph nodes,liver,spleen,... . Extraosseouse involvement in LCH is much less common than osseouse involvement. Liver involvement is relatively common manifestation(40-60%) in multiorgan system disease. Histopathologically liver shows periportal langerhans cell infiltration, with features of granulomatouse and xanthomatous phases.
LCH include four variants: