Revision 2 for 'Extraosseous langerhans cell histiocytosis'

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Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a rare proliferative disorder that characterized by granulomatous infiltration of the lung, bone,skin,lymph nodes,liver,spleen,... . Extraosseouse involvement in LCH is much less common than osseouse involvement. Liver involvement is relatively common manifestation(40-60%) in multiorgan system disease. Histopathologically liver shows periportal langerhans cell infiltration, with features of granulomatouse and xanthomatous phases.

LCH include four variants:

Hashimoto-Pritzker disease

Letterer-Siwe disease

Hand-Schuller-Christian disease

Eosinophilic granuloma

 

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