Eye of the tiger sign

Case contributed by Dr Yune Kwong

Presentation

3 year progressive left hemidystonia, decreased cognition and speech, orobuccal dyskinesia.

Patient Data

Age: 61-year-old
Gender: Female
MRI

MRI Brain

T2 shows central area of globus pallidus hyperintensity, with surrounding low intensity, giving the 'eye of the tiger' sign.

Case Discussion

Eye of the tiger sign is seen in Hallervorden Spatz syndrome, also known as pantothenate kinase-associated neurodegeneration (PKAN). This sign describes characteristic low signal surrounding a central region of of high signal in the anteriomedial globus pallidus on T2. Pathologically, the low signal corresponds to abnormal iron deposition, and the high signal corresponds to gliosis, vacuolisation and increased water content.

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Case information

rID: 41008
Case created: 11th Nov 2015
Last edited: 11th Nov 2015
Inclusion in quiz mode: Included

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