False positive MRI prostate - focal prostatitis

Case contributed by Dr Chris O'Donnell


Previous T1C Gleason 3+3 = 6 prostate cancer on active surveillance. Slight increase in PSA. MRI to determine extent of tumour infiltration

Patient Data

Age: 55 years
Gender: Male

Large area of diffuse T2 hypointensity in the peripheral zone of right base and mid prostate.  Restricted diffusion on DWI and the ADC map with increased early enhancement following bolus IV Gad injection.  No capsular breach.  Right lobe is perhaps a little smaller than the left.  This indicates at least a PIRADS 4 lesion requiring biopsy for confirmation of neoplasm.

Case Discussion

MRI prostate is useful at detecting and locally staging prostate cancer but there are false positives.  Features of cancer are T2 hypointensity with restricted diffusion and early, rapid washout enhancement as in this case.  Transperineal template biopsy (with fused US guidance targeting the right-sided MRI findings) in this case showed "patchy mixed inflammatory cell infiltrate" but no malignancy in all right sided biopsies and only "moderate acinar atrophy" in the left side.  No malignancy detected.  This patient, therefore, has focal right-sided (asymptomatic) prostatitis causing a false positive for malignancy on MRI and increase in PSA.

PlayAdd to Share

Case information

rID: 42151
Published: 7th Jan 2016
Last edited: 14th Aug 2019
System: Urogenital
Inclusion in quiz mode: Excluded

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.