Fibrolamellar hepatocellular carcinoma

Case contributed by Dr Mauricio Macagnan


Incidental finding on ultrasound.

Patient Data

Age: 31
Gender: Female

Total Abdominal Ultrasonography

The liver contour is regular, with slightly heterogeneous parenchyma. In segment VIII, there is a slightly hypoechoic nodule, ill-defined margins, measuring about 8.2 x 8.1 x 5.3 cm, of undetermined aetiology.

The dimensions and contour of the liver are preserved. There is a nodular lesion in segment VIII of the right hepatic lobe, with heterogeneous contrast enhancement in the arterial phase and tending to homogenize in the late phase, bordered by halo hypoattenuation.

A solid 6.6cm nodule in segment VIII, with high signal on T2-weighted sequence and DWI and intermediate signal intensity on the T1-weighted sequence. It has a markedly hypointense central scar on T2.
The displays slightly heterogeneous enhancement in the arterial phase, becoming homogeneous in the following stages, with the exception of its central scar.

One way to differentiate between the Fibrolamellar Hepatocellular Carcinoma (FHC) and Focal Nodular Hyperplasia is through the central scar analyzed in sequence T2, where the FHC has low T2 signal and FNH has high T2 signal.

Case Discussion

Hepatic nodules are frequent findings in imaging and appropriate differentiation through imaging and clinical history helps to monitor and manage these patients.

This patient had an incidental liver nodule during abdominal ultrasound. It was worked up through computed tomography and MRI.

In this case, the difference between FHC and FNH is important and can be diagnosed with conventional MRI and contrast. Some cases may require specific contrasts, such as Primovist, to aid in differentiation when examination with conventional gadolinium is not sufficiently clear.

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Case information

rID: 45173
Published: 19th May 2016
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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