Frontotemporal dementia (language variant)

Case contributed by A.Prof Frank Gaillard

Presentation

Expressive dysphasia progressive over 2 years

Patient Data

Age: 50 years
Gender: Male

MRI brain

Modality: MRI

Marked asymmetric atrophy of the frontal pole of the left temporal lobe as well as the left frontal opercular region. The left fusiform and inferior temporal gyri are particularly atrophic with dilated temporal horn. Associated mild increased subcortical FLAIR signal. The rest of the brain, including the hippocampi demonstrate involutional change, exaggerated for age.  

No intra-cranial mass lesions, acute haemorrhages or collections.  No acute or established infarcts.  Mild bi-hemispheric chronic white matter ischaemic change. Small anterior falcine calcification.

Conclusion:

Findings are in keeping with language variant of frontotemporal dementia. 

SPECT

Modality: Nuclear medicine

SPECT perfusion studies show severe perfusion reduction in the left temporal lobe with mild perfusion reduction extending into the left frontal and parietal cortex. Right temporal lobe perfusion uninvolved. Posterior cingulate perfusion preserved.

OVERALL IMPRESSION

The severe perfusion reduction involving the left temporal lobe is consistent with language variant of frontotemporal dementia. 

Case Discussion

Typical appearances of advanced frontotemporal dementia. 

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Case Information

rID: 22224
Case created: 21st Mar 2013
Last edited: 2nd Nov 2015
Inclusion in quiz mode: Included

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