Frontotemporal dementia (language variant)

Case contributed by A.Prof Frank Gaillard


Expressive dysphasia progressive over 2 years

Patient Data

Age: 50 years
Gender: Male

MRI brain

Marked asymmetric atrophy of the frontal pole of the left temporal lobe as well as the left frontal opercular region. The left fusiform and inferior temporal gyri are particularly atrophic with dilated temporal horn. Associated mild increased subcortical FLAIR signal. The rest of the brain, including the hippocampi demonstrate involutional change, exaggerated for age.  

No intra-cranial mass lesions, acute hemorrhages or collections.  No acute or established infarcts.  Mild bi-hemispheric chronic white matter ischemic change. Small anterior falcine calcification.


Findings are in keeping with language variant of frontotemporal dementia. 

Nuclear medicine


SPECT perfusion studies show severe perfusion reduction in the left temporal lobe with mild perfusion reduction extending into the left frontal and parietal cortex. Right temporal lobe perfusion uninvolved. Posterior cingulate perfusion preserved.


The severe perfusion reduction involving the left temporal lobe is consistent with language variant of frontotemporal dementia. 

Case Discussion

Typical appearances of advanced frontotemporal dementia. 

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Case information

rID: 22224
Published: 21st Mar 2013
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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