Fundic gland polyp: histology
Incidental finding in gastric sleeve resection.
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The incidental 2mm polyp shows histological features of benign fundic gland polyp.
The gastric mucosa is focally thickened with a polypoid outline, with underlying rounded to angular dilated glands.
The polyp is formed by loose aggregates of dilated glands within oxyntic (acid-secreting) mucosa ie. gastric fundus and body.
The dilated glands are lined predominantly by parietal cells and smaller proportions of chief cells.
1 case question available
Fundic gland polyps are very common benign polyps of the stomach. Whilst most are sporadic, there is an increased incidence with proton pump inhibitor (PPI) therapy and an association with familial adenomatous polyposis (FAP), although the latter appear to display a different mutation profile.