Gallbladder adenocarcinoma

Case contributed by Dr Domenico Nicoletti


Dyspepsia with right upper quadrant pain.

Patient Data

Age: 75 years
Gender: Male

There is a gallbladder stone and a coarse hyperechoic wall lesion, measuring 1.8 x 2.5 cm.


There is a large polyp at gallbladder fundus that shows arterial phase enhancement that persists into later phases. There is also a large gallstone. The bile ducts aren't dilated. The liver is unremarkable.


Histologic analysis, post cholecystectomy.


Well-differentiated adenocarcinoma infiltrating the lamina propria in villous adenoma with high-grade epithelial dysplasia.

Chronic lithiasic erosive cholecystitis.

Presence of a metastasis-free lymph node.

Free excision margin.


Case Discussion

Gallbladder cancer is a rare disease that often arises in the setting of chronic inflammation.

In the vast majority of patients the source of this chronic inflammation is cholesterol gallstones.

Other more unusual causes of chronic inflammation are primary sclerosing cholangitis, ulcerative colitis, liver flukes, chronic Salmonella typhi and paratyphi infections.

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Case information

rID: 50235
Published: 1st Feb 2019
Last edited: 14th Aug 2019
Inclusion in quiz mode: Excluded

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