Gangliocytoma: frontal lobe

Case contributed by A.Prof Frank Gaillard
Modality: MRI

An enhancing multicystic mass in the superior frontal gyrus of the right frontal lobe is demonstrated with surrounding vasogenic oedema. It appears to be centred on the white matter. 

Case Discussion

The patient went on to have a craniotomy and biopsy. 

Histology

Microscopic Description:

Sections show multiple small fragments of neuropil containing focal collections of atypical ganglion cell neurons. These cells have large round nuclei with prominent nucleoli, abundant cytoplasm and peripheral Nissl substance. The cells are atypical in their morphology, orientation and spacial arrangement. Many blood vessels are surrounded by small cuffs of reactive lymphocytes. The intervening neuropil shows a mild degree of reactive gliosis, occasional axonal steroids and multiple small calcified deposits, resembling psammoma bodies. There does not appear to be any neoplastic glial component to this lesion.

Final Diagnosis: gangliocytoma.

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Case Information

rID: 5500
Case created: 27th Jan 2009
Last edited: 3rd Dec 2015
Inclusion in quiz mode: Included

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