Gastrointestinal stromal tumour - gastric

Case contributed by Dr Andrew Ryan

Presentation

Abdominal pain for investigation. Incidental finding on gastroscopy - now resection.

Patient Data

Age: 55
Gender: Male
Modality: Pathology

Macroscopic features;

  • solid and cystic/haemorrhagic
  • pale, homogenous in solid areas 
  • centered in submucosa/muscle wall, with intact overlying mucosa 
Modality: Pathology

Microscopic features;

  • 'spindle cell' pattern
  • cells arranged in whorls and irregular fascicles
  • cells have spindled to elongate nuclei (these tumours can be 'epithelioid')
  • positive staining for c-Kit
  • important microscopic prognostic features include;
    • low mitotic activity (we give a count of number of mitoses/50 high power fields [x400])
    • no necrosis
    • uniform low cellularity
    • minimal pleomorphism

Case Discussion

The important prognostic features in this case include; 

  • location (gastric)
  • size (55mm)
  • mitotic activity (up to 2 per 50 hpf)

Using published data (see reference below), this case has a 'low' risk of progessive disease. 

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Case Information

rID: 16554
Case created: 28th Jan 2012
Last edited: 28th Aug 2016
Inclusion in quiz mode: Excluded

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