Giant cell tumor of bone - lung metastasis
Updates to Study Attributes
The sections from each lung wedge showed similar features, with each containing a well circumscribed, solid lesion with a diffuse patternless architecture and composed of relatively monomorphic mononuclear cells along with somewhat evenly distributed multi-nucleated giant cells. Mononuclear and multinucleated cells display similar nuclear morphology. Mitotic figures are present in small numbers. There is mild focal haemorrhage and no necrosis. The surrounding alveolated lung parenchyma shows no significant abnormality.
40x H&E: Low-power view showing sharp circumscription from otherwise normal-appearing alveolated lung parenchyma. The tumour is solid and displays a diffuse, patternless architecture.
100x H&E: Medium-power view showing patternless pattern and mononuclear cells with relatively evenly distributed multinucleated cells.
200x H&E: High-power view showing relatively monophorphous appearance to cells. At this power, the similarity in nuclear features between mononuclear and multinucleated cells can be appreciated. There is no significant nuclear pleomorphism.
Image Pathology (H&E) (update)
Image Pathology (H&E) (update)
Image Pathology (H&E) (update)
Updates to Case Attributes
Whilst primary giant cell tumours (GCT) of bone are often considered benign in nature (albeit locally aggressive), distant metastases occur in a small minority (between 1-9%, depending on the study), with pulmonary metastases being the most common site.
Unlike most other distant metastatic diseasediseases, metastatic GCT is not necessarily associated with a poor prognostic outcome, with metastatectomymetastasectomy (where possible) being curative in many patients.
In the setting of known primary GCT this diagnosis is relatively straightforward, however, in the absence of such a history, a wider differential diagnosis must be considered.
-<p>Whilst primary giant cell tumours (GCT) of bone are often considered benign in nature (albeit locally aggressive), distant metastases occur in a small minority (between 1-9%, depending on the study), with pulmonary metastases being the most common site. </p><p>Unlike most other distant metastatic disease, metastatic GCT is not necessarily associated with a poor prognostic outcome, with metastatectomy (where possible) being curative in many patients. </p><p>In the setting of known primary GCT this diagnosis is relatively straightforward, however, in the absence of such a history, a wider differential diagnosis must be considered. </p>- +<p>Whilst primary giant cell tumours (GCT) of bone are often considered benign in nature (albeit locally aggressive), distant metastases occur in a small minority (between 1-9%, depending on the study), with pulmonary metastases being the most common site. </p><p>Unlike most other distant metastatic diseases, metastatic GCT is not necessarily associated with a poor prognostic outcome, with metastasectomy (where possible) being curative in many patients. </p><p>In the setting of known primary GCT this diagnosis is relatively straightforward, however, in the absence of such a history, a wider differential diagnosis must be considered. </p>
References changed:
- 1. Viswanathan S and Jambhekar NA, Metastatic Giant Cell Tumor of Bone: Are There Associated Factors and Best Treatment Modalities?; Clin Orthop Relat Res. 2010 Mar; 468(3): 827–833 <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816751/">Pubmed complete article</a><div class="ref_v2"></div>
- Viswanathan S and Jambhekar NA, Metastatic Giant Cell Tumor of Bone: Are There Associated Factors and Best Treatment Modalities?; Clin Orthop Relat Res. 2010 Mar; 468(3): 827–833 <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816751/">Pubmed complete article</a><div class="ref_v2"></div>
Systems changed:
- Oncology
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