Case contributed by Bahman Rasuli


Headaches and seizures.

Patient Data

Age: 40 years
Gender: Female

28*32*38 mm right temporal lobe abnormal signal intra-axial mass lesion with a central necrotic component and thick irregular wall enhancement associated with marked vasogenic edematous changes.

Mass effect and vasogenic edema causing the midline shift, effacement of right perimesencephalic cistern and pressure effect on the right cerebral peduncle.

Case Discussion

The mass was resected and microscopic description revealed:

Sections of the brain reveal a neoplastic tissue with marked nuclear crowding and atypia, mitotic activity, microvascular proliferation, and palisading necrosis. also in a focus presence of fried-egg patterns delineate chicken wire network of capillaries is noted.

Diagnosis: Glioblastoma with an oligodendroglial component.

IHC results:

Strongly cytoplasmic immunoreactivity of tumor cells. 

Final diagnosis: 

IDH mutant glioblastoma(secondary glioblastoma)

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