Glioblastoma

Case contributed by A.Prof Frank Gaillard

Presentation

Seizure.

Patient Data

Age: 65 years
Gender: Male

MRI brain

Modality: MRI

MRI of the brain demonstrates a large heterogeneously enhancing tumour in the left parietal lobe extending down towards the ventricle. It has a non-enhancing central fluid signal component suggesting central necrosis. There is surrounding oedema with mass effect. 

The patient went on to have a resection. 

Histology

MICROSCOPIC DESCRIPTION :The  sections   show  cerebral   tissue   containing  a  diffusely infiltrating moderately cellular  tumour, with scattered areas of necrosis. There is associated  microvascular  proliferation, with  thrombosed vessels evident.   The  tumour  cells  are  generally   elongate,  with  inapparent cytoplasmic  outlines and  associated  with  eosinophilic glial  processes. Nuclei are oval or  elongate, generally  with hyperchromatic  chromatin and frequent mitotic  figures seen.   Tumour cells  show variable  perineuronal satellitosis.  No oligodendroglial component is recognised.

FINAL DIAGNOSIS: Astrocytoma, WHO grade 4 (glioblastoma).

Case Discussion

This case illustrates typical appearances of a high grade glioma (glioblastoma). 

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Case Information

rID: 22205
Case created: 20th Mar 2013
Last edited: 2nd Sep 2016
Inclusion in quiz mode: Included

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