Glioblastoma (butterfly)

Case contributed by A.Prof Frank Gaillard

Presentation

Headache and personality change.

Patient Data

Age: 80 years
Gender: Female

CT brain

Modality: CT

Extensive bifrontal tumour involving the corpus callosum associated with moderate vasogenic oedema.

The patient went on to have biopsy. 

Histology

MICROSCOPIC DESCRIPTION: Paraffin sections show fragments of a densely hypercellular glial tumour.  Tumour cells are a mixture of fibrillary and gemistocytic astrocytes and several markedly pleomorphic multinucleated tumour giant cells are also noted.  Scattered mitotic figures are identified. There are foci of necrosis as well as microvascular proliferation with endothelial cell hyperplasia.  The overall features are of glioblastoma multiforme (WHO grade IV).  An oligodendroglial component is not identified.

FINAL DIAGNOSIS: Glioblastoma multiforme (WHO Grade IV).

Case Discussion

Typical appearances of a butterfly glioma. 

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Case Information

rID: 23097
Case created: 22nd May 2013
Last edited: 1st Nov 2015
Inclusion in quiz mode: Included

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