Glioblastoma (GBM)

Case contributed by A.Prof Frank Gaillard

Presentation

Headaches.

Patient Data

Age: Adult
Modality: MRI

Heterogeneous enhancing mass with central non-enhancement involves both white matter and cortex and extends towards the ventricle. 

Case Discussion

The patient went on to have a resection. 

Histology

Microscopic Description: 

Sections show the specimen to consist predominantly of necrotic tissue, in areas containing viable glioma that is high grade. The tumor cells display small cell morphologic characteristics, possible oligodendroglial features, and astrocytic elements with a fibrillar appearance. Mitotic figures are identified. Vascular proliferation is observed, including glomeruloid aggregates proliferating capillaries. As previously mentioned, tumor necrosis is extensive. Abnormally large ectatic vascular structures are also seen, and are consistent with a vascular malformation. Several vessels are thrombosed.

Final Diagnosis: Glioblastoma (GBM) WHO Grade IV

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Case Information

rID: 5132
Case created: 8th Dec 2008
Last edited: 14th Feb 2016
Inclusion in quiz mode: Included

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