Glioblastoma (GBM) with PNET component

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: Adult
Modality: MRI

Heterogeneous left frontal lobe mass with areas of non-enhancement embedded within enhancing tumour. The tumour extends accross the corpus callosum. 

Case Discussion

The patient went on to have a biopsy. 


Paraffin sections show a densely hypercellular glial tumour. This is composed predominantly of pleomorphic, strongly GFAP immunoreactive astrocytic cells with irregularly shaped hyperchromatic nuclei and coarse processes. Scattered gemistocytic and multinucleated forms are also noted. There are frequent mitotic figures, prominent vascular endothelial cell hyperplasia and areas of confluent necrosis. The features are of glioblastoma. WHO grade IV.

Tumour in other specimens is composed of smaller cells with round, oval and angulated hyperchromatic nuclei and a small amount of cytoplasm. The majority of these cells show strong immunostaining for synaptophysin. Patchy strong GFAP staining is also noted. The features in this component are of primitive neuroectodermal tumour (PNET)

Final diagnosis:  Glioblastoma (GBM) with PNET component

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Case Information

rID: 9015
Case created: 13th Mar 2010
Last edited: 28th Sep 2015
Tags: gbm, glioma
Inclusion in quiz mode: Included

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