Glioblastoma IDH wild-type (haemorrhagic)

Case contributed by A.Prof Frank Gaillard

Presentation

Sudden onset right hemiplegia

Patient Data

Age: 65 years
Gender: Female

A large parenchymal haemorrhage is present with extension into the ventricle. Areas of enhancement are seen related to the bleed, as well as posteriorly (ring enhancing lesion). The splenium appears of low attenuation and thickened. 

MRI better delineates the CT features, and further demonstrates extensive white matter change with thickening of the splenium of the corpus callosum. Enhancement both around the haemorrhage and as a separate ring enhancing lesion is present. 

Case Discussion

The patient went on to have an excision. 

Histology

MICROSCOPIC DESCRIPTION:

The sections show evidence of organising haemorrhage with sheets of foamy macrophages and many intermixed blood vessels. A few other fragments show a densely cellular astrocytic tumour. The tumour cells have elongated, angulated and hyperchromatic nuclei. Scattered mitotic figures are identified. Microvascular proliferation is inconspicuous. Small foci of tumour cell necrosis are seen. The tumour cells are GFAP, p53 and MGMT immunostains positive. The topoisomerase index is about 15%. IDH-1 and melan-A are negative. The features are those of glioblastoma.

FINAL DIAGNOSIS: glioblastoma (WHO Grade IV).

 

Note: Although this tumour is entirely consistent with IDH wild-type molecular subtype, strictly speaking, to conclusively establish this, IDH would need to be sequenced to ensure that a non-IDH1 R132H mutation was present. In practice, an IDH1 R132H negative tumour in an individual over 55-years-of-age makes the possibility of this being IDH mutant remote (<1%), and sequencing is not felt to be necessary by many institutions, and not recommended by the WHO classification of CNS tumours (2016). 

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Case information

rID: 29068
Case created: 1st May 2014
Last edited: 26th May 2017
Inclusion in quiz mode: Included

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