Glioblastoma - mixed histology with gemistocytic and oligodendroglial components

Case contributed by A.Prof Frank Gaillard

The patient went on to have a craniotomy and excision. 

Histology

Microscopic Description: Sections show a glioma composed predominantly of gemistocytic and micro-gemistocytic tumour cells. Oligodendroglial elements are focally seen. Focal endothelial cell proliferation is noted, and a localized area of recent necrosis is identified. Occasional mitoses are seen.

Final Diagnosis: glioblastoma

Comment: The gemistocytic and micro-gemistocytic elements of this malignant glioma could be astrocytic or oligodendroglial. The latter is favoured.

Case Discussion

The presence of necrosis and endothelial proliferation is consistent with a WHO grade IV tumour. 

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Case Information

rID: 5276
Case created: 29th Dec 2008
Last edited: 7th Dec 2015
Inclusion in quiz mode: Included

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